THE 2-MINUTE RULE FOR MIF

This observation is intriguing for 2 other good reasons. 1st, it implies that cells might take up MIF by ENDOCYTOSIS. provided the ample intracellular expression of MIF, it'd be requested what benefit would the mobile acquire by making use of endocytosed MIF in lieu of intracellular MIF. Endocytosis of MIF might manifest either in a very receptor-d

MIF-2 in distinction to MIF appears to lack the necessary CXCR-interacting motifs needed for activation, and it is thought to exert a more selective motion in activating the tissue-protecting CD74 signaling pathway. Having said that, MIF triggers the CD74/CD44/AMPK receptor signaling pathway, which promotes glucose uptake in cardiomyocytes and safe